rs71327024 Associated with COVID-19 Hospitalization Reduces <i>CXCR6</i> Promoter Activity in Human CD4<sup>+</sup> T Cells via Disruption of c-Myb Binding

rs71327024 Associated with COVID-19 Hospitalization Reduces <i>CXCR6</i> Promoter Activity in Human CD4<sup>+</sup> T Cells via Disruption of c-Myb Binding

Single-nucleotide polymorphism rs71327024 located in the human 3p21.31 locus has been associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21.31 locus contains several genes encoding chemokine receptors potentially relevant to severe COVID-19. In particular, CXCR6, wh...

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Bibliographic Details
Main Authors: Aksinya N. Uvarova, Ekaterina M. Stasevich, Alina S. Ustiugova, Nikita A. Mitkin, Elina A. Zheremyan, Savely A. Sheetikov, Ksenia V. Zornikova, Apollinariya V. Bogolyubova, Mikhail A. Rubtsov, Ivan V. Kulakovskiy, Dmitry V. Kuprash, Kirill V. Korneev, Anton M. Schwartz
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
3p21.31 locus
COVID-19
CXCR6
T helpers
c-Myb
non-coding SNP
Online Access:https://www.mdpi.com/1422-0067/24/18/13790

Internet

https://www.mdpi.com/1422-0067/24/18/13790

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