Differential Effects of Alarmins on Human and Mouse Basophils

Differential Effects of Alarmins on Human and Mouse Basophils

Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation. We evaluated the in vitro effects of IL-33, TSLP, and IL-25, alone and in combination with IL-3 on purified periphera...

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Bibliographic Details
Main Authors: Adriana R. Gambardella, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Giovanna Schiavoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
allergy
asthma
basophils
IL-4
IL-13
IL-25
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.894163/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.894163/full

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