Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity

Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity

The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy balance and metabolism and binds glycogen, the primary storage form of glucose in liver and skeletal muscle. The effects of disrupting whole-body AMPK-glycogen interactions on exercise capacity and substrate utilizatio...

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Bibliographic Details
Main Authors: Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Physiology
Subjects:
AMP-activated protein kinase
carbohydrate binding module
glycogen
skeletal muscle
exercise
energy utilization
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.859246/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.859246/full

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