Expression status of p53 and organic cation transporter 1 is correlated with poor response to preoperative chemotherapy in esophageal squamous cell carcinoma

Expression status of p53 and organic cation transporter 1 is correlated with poor response to preoperative chemotherapy in esophageal squamous cell carcinoma

Abstract Background Esophageal squamous cell carcinoma (ESCC) is a highly malignant neoplasm. DNA-damaging drugs, such as cisplatin (CDDP) and 5-fluorouracil (5-FU), are most frequently used in preoperative chemotherapy for ESCC. However, the response to preoperative chemotherapy varies among patien...

Full description

Bibliographic Details
Main Authors: Masahiro Izutsu, Takanori Domoto, Shingo Kamoshida, Hiroyuki Ohsaki, Hiroshi Matsuoka, Yusuke Umeki, Kazuya Shiogama, Masaya Hirayama, Koichi Suda, Ichiro Uyama
Format: Article
Language:English
Published: BMC 2022-04-01
Series:World Journal of Surgical Oncology
Subjects:
Cisplatin
Esophageal squamous cell carcinoma
Preoperative chemotherapy
Organic cation transporter 1
p53
Online Access:https://doi.org/10.1186/s12957-022-02571-9

Internet

https://doi.org/10.1186/s12957-022-02571-9

Similar Items