Generation of H11-albumin-rtTA Transgenic Mice: A Tool for Inducible Gene Expression in the Liver

Generation of H11-albumin-rtTA Transgenic Mice: A Tool for Inducible Gene Expression in the Liver

The modification of the mouse genome by site-specific gene insertion of transgenes and other genetic elements allows the study of gene function in different developmental stages and in the pathogenesis of diseases. Here, we generated a “genomic safe harbor” Hipp11 (H11) locus-specific knock-in trans...

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Bibliographic Details
Main Authors: Yu-Shan Li, Ran-Ran Meng, Xiu Chen, Cui-Ling Shang, Hong-Bin Li, Tao-Jun Zhang, Hua-Yang Long, Hui-Qi Li, Yi-Jing Wang, Feng-Chao Wang
Format: Article
Language:English
Published: Oxford University Press 2019-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Hipp11
albumin promoter
doxycycline
Tet-on system
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200963

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