The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis.

Bibliographic Details
Main Authors: Philipp Neumann, Nicolas Jaé, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus Krüger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon, Stefanie Dimmeler
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02431-1

Internet

https://doi.org/10.1038/s41467-017-02431-1

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