Mice Harboring a Non-Functional <i>CILK1/ICK</i> Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant <i>CILK1/ICK</i>

Mice Harboring a Non-Functional <i>CILK1/ICK</i> Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant <i>CILK1/ICK</i>

CILK1 (ciliogenesis associated kinase 1)/ICK (intestinal cell kinase) is a highly conserved protein kinase that regulates primary cilia structure and function. <i>CILK1</i> mutations cause a wide spectrum of human diseases collectively called ciliopathies. While several <i>CILK1<...

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Bibliographic Details
Main Authors: Kathryn A. Salvati, Ashley J. Mason, Casey D. Gailey, Eric J. Wang, Zheng Fu, Mark P. Beenhakker
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
epilepsy
ciliopathy
primary cilium
kinase
seizure
opisthotonos
Online Access:https://www.mdpi.com/1422-0067/22/16/8875

Internet

https://www.mdpi.com/1422-0067/22/16/8875

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