Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB<sup>0,+</sup>) Selectively Reduces Access for Cationic Amino Acids and Derivatives

Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB<sup>0,+</sup>) Selectively Reduces Access for Cationic Amino Acids and Derivatives

SLC6A14 (ATB<sup>0,+</sup>) is unique among SLC proteins in its ability to transport 18 of the 20 proteinogenic (dipolar and cationic) amino acids and naturally occurring and synthetic analogues (including anti-viral prodrugs and nitric oxide synthase (NOS) inhibitors). SLC6A14 mediates...

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Bibliographic Details
Main Authors: Catriona M. H. Anderson, Noel Edwards, Andrew K. Watson, Mike Althaus, David T. Thwaites
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
amino acid transporter
solute carrier
SLC
membrane transport
SLC6A14
SLC6
Online Access:https://www.mdpi.com/2218-273X/12/10/1404

Internet

https://www.mdpi.com/2218-273X/12/10/1404

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