Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host

Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host

IntroductionAround 10% of the coding potential of Mycobacterium tuberculosisis constituted by two poorly understood gene families, the pe and ppe loci, thought to be involved in host-pathogen interactions. Their repetitive nature and high GC content have hindered sequence analysis, leading to exclus...

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Bibliographic Details
Main Authors: Paula Josefina Gómez-González, Anna D. Grabowska, Leopold D. Tientcheu, Anthony G. Tsolaki, Martin L. Hibberd, Susana Campino, Jody E. Phelan, Taane G. Clark
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Microbiology
Subjects:
Mycobacerium tuberculosis
genomics
MTBC
diversity
pe/ppe family of genes
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1244319/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1244319/full

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