Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells
Accumulation of advanced glycation endproducts (AGEs) plays a pivotal role in the pathophysiology of diabetic complications. In this study, we evaluated the protective activities of water/ethanol (1:1, v/v) extract (WEE) and its fractions from Chinese olive (Canarium album L.) fruit on AGEs-induced...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-12-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616303231 |
| _version_ | 1818415714148548608 |
|---|---|
| author | Chiung-Tsun Kuo Tzu-Hao Liu Tai-Hao Hsu Fang-Yi Lin Hui-Yin Chen |
| author_facet | Chiung-Tsun Kuo Tzu-Hao Liu Tai-Hao Hsu Fang-Yi Lin Hui-Yin Chen |
| author_sort | Chiung-Tsun Kuo |
| collection | DOAJ |
| description | Accumulation of advanced glycation endproducts (AGEs) plays a pivotal role in the pathophysiology of diabetic complications. In this study, we evaluated the protective activities of water/ethanol (1:1, v/v) extract (WEE) and its fractions from Chinese olive (Canarium album L.) fruit on AGEs-induced endothelial dysfunction. The WEE and its fractions could scavenge free radicals, inhibit AGEs formation and reduce the overgeneration of AGEs-induced ROS in endothelial cells. They also increased AGEs-mediated loss of glutathione level and SOD activity. AGEs stimulated monocyte adhesion, ICAM-1 expression and IκBα phosphorylation, which were inhibited by WEE and its fractions. Furthermore, they reduced AGEs-induced inflammatory cytokines including TNFα, interleukin-1β and interleukin-6 level in monocytes. Nine compounds such as gallic acid, methyl gallate, ethyl gallate, scopoletin, ferulic acid, ellagic acid, and rutin were identified. These findings indicated that Chinese olive fruit attenuated AGEs-mediated endothelial dysfunction by ameliorating inflammation and oxidant stress responses via inhibiting NF-κB pathway. |
| first_indexed | 2024-12-14T11:39:23Z |
| format | Article |
| id | doaj.art-e25c4599757f422d874005ca4638effb |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:39:23Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e25c4599757f422d874005ca4638effb2022-12-21T23:02:55ZengElsevierJournal of Functional Foods1756-46462016-12-0127526536Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cellsChiung-Tsun Kuo0Tzu-Hao Liu1Tai-Hao Hsu2Fang-Yi Lin3Hui-Yin Chen4Department of Food Science and Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan; Department of Bioindustry Technology, Da-Yeh University, Changhua, TaiwanDepartment of Food Science and Technology, Central Taiwan University of Science and Technology, Taichung, TaiwanDepartment of Bioindustry Technology, Da-Yeh University, Changhua, TaiwanDepartment of Bioindustry Technology, Da-Yeh University, Changhua, TaiwanDepartment of Food Science and Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan; Corresponding author. Department of Food Science and Technology, Central Taiwan University of Science and Technology, 666, Putzu Road, Peitun District, Taichung 40601, Taiwan. Fax: 886 4 22396771.Accumulation of advanced glycation endproducts (AGEs) plays a pivotal role in the pathophysiology of diabetic complications. In this study, we evaluated the protective activities of water/ethanol (1:1, v/v) extract (WEE) and its fractions from Chinese olive (Canarium album L.) fruit on AGEs-induced endothelial dysfunction. The WEE and its fractions could scavenge free radicals, inhibit AGEs formation and reduce the overgeneration of AGEs-induced ROS in endothelial cells. They also increased AGEs-mediated loss of glutathione level and SOD activity. AGEs stimulated monocyte adhesion, ICAM-1 expression and IκBα phosphorylation, which were inhibited by WEE and its fractions. Furthermore, they reduced AGEs-induced inflammatory cytokines including TNFα, interleukin-1β and interleukin-6 level in monocytes. Nine compounds such as gallic acid, methyl gallate, ethyl gallate, scopoletin, ferulic acid, ellagic acid, and rutin were identified. These findings indicated that Chinese olive fruit attenuated AGEs-mediated endothelial dysfunction by ameliorating inflammation and oxidant stress responses via inhibiting NF-κB pathway.http://www.sciencedirect.com/science/article/pii/S1756464616303231Chinese oliveAdvanced glycation end-products (AGEs)Endothelial dysfunctionInflammationOxidative stress |
| spellingShingle | Chiung-Tsun Kuo Tzu-Hao Liu Tai-Hao Hsu Fang-Yi Lin Hui-Yin Chen Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells Journal of Functional Foods Chinese olive Advanced glycation end-products (AGEs) Endothelial dysfunction Inflammation Oxidative stress |
| title | Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells |
| title_full | Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells |
| title_fullStr | Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells |
| title_full_unstemmed | Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells |
| title_short | Protection of Chinese olive fruit extract and its fractions against advanced glycation endproduct-induced oxidative stress and pro-inflammatory factors in cultured vascular endothelial and human monocytic cells |
| title_sort | protection of chinese olive fruit extract and its fractions against advanced glycation endproduct induced oxidative stress and pro inflammatory factors in cultured vascular endothelial and human monocytic cells |
| topic | Chinese olive Advanced glycation end-products (AGEs) Endothelial dysfunction Inflammation Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616303231 |
| work_keys_str_mv | AT chiungtsunkuo protectionofchineseolivefruitextractanditsfractionsagainstadvancedglycationendproductinducedoxidativestressandproinflammatoryfactorsinculturedvascularendothelialandhumanmonocyticcells AT tzuhaoliu protectionofchineseolivefruitextractanditsfractionsagainstadvancedglycationendproductinducedoxidativestressandproinflammatoryfactorsinculturedvascularendothelialandhumanmonocyticcells AT taihaohsu protectionofchineseolivefruitextractanditsfractionsagainstadvancedglycationendproductinducedoxidativestressandproinflammatoryfactorsinculturedvascularendothelialandhumanmonocyticcells AT fangyilin protectionofchineseolivefruitextractanditsfractionsagainstadvancedglycationendproductinducedoxidativestressandproinflammatoryfactorsinculturedvascularendothelialandhumanmonocyticcells AT huiyinchen protectionofchineseolivefruitextractanditsfractionsagainstadvancedglycationendproductinducedoxidativestressandproinflammatoryfactorsinculturedvascularendothelialandhumanmonocyticcells |