miR-539-5p regulates Srebf1 transcription in the skeletal muscle of diabetic mice by targeting DNA methyltransferase 3b

miR-539-5p regulates Srebf1 transcription in the skeletal muscle of diabetic mice by targeting DNA methyltransferase 3b

Aberrant DNA methylation is associated with diabetes, but the precise regulatory events that control the levels and activity of DNA methyltransferases (DNMTs) is not well understood. Here we show that miR-539-5p targets Dnmt3b and regulates its cellular levels. miR-539-5p and Dnmt3b show inverse pat...

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Bibliographic Details
Main Authors: Devesh Kesharwani, Amit Kumar, Ashima Rizvi, Malabika Datta
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DNMT3b
miR-539-5p
DNA methylation
Srebf1
diabetes
skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002128

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http://www.sciencedirect.com/science/article/pii/S2162253122002128

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