Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII activity to mitochondrial electron transport chain...

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Bibliographic Details
Main Authors: Seyi Falekun, Jaime Sepulveda, Yasaman Jami-Alahmadi, Hahnbeom Park, James A Wohlschlegel, Paul A Sigala
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
malaria
organelle adaptation
mitochondria
acyl carrier protein
Fe-S cluster synthesis
Online Access:https://elifesciences.org/articles/71636

Internet

https://elifesciences.org/articles/71636

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