Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

Abstract Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and-error search for immunogen modifications that impro...

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Bibliographic Details
Main Authors: Rory Henderson, Kara Anasti, Kartik Manne, Victoria Stalls, Carrie Saunders, Yishak Bililign, Ashliegh Williams, Pimthada Bubphamala, Maya Montani, Sangita Kachhap, Jingjing Li, Chuancang Jaing, Amanda Newman, Derek W. Cain, Xiaozhi Lu, Sravani Venkatayogi, Madison Berry, Kshitij Wagh, Bette Korber, Kevin O. Saunders, Ming Tian, Fred Alt, Kevin Wiehe, Priyamvada Acharya, S. Munir Alam, Barton F. Haynes
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53120-9

Internet

https://doi.org/10.1038/s41467-024-53120-9

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