Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established clearance pathway for lipid alkenals includes conjugation to gl...

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Bibliografiske detaljer
Main Authors:	Michele Scian, Lorela Paço, Taylor A. Murphree, Laura M. Shireman, William M. Atkins
Format:	Article
Sprog:	English
Udgivet:	MDPI AG 2023-02-01
Serier:	Biomolecules
Fag:	enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism
Online adgang:	https://www.mdpi.com/2218-273X/13/2/329

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