Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established clearance pathway for lipid alkenals includes conjugation to gl...

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Detalles Bibliográficos
Main Authors:	Michele Scian, Lorela Paço, Taylor A. Murphree, Laura M. Shireman, William M. Atkins
Formato:	Artigo
Idioma:	English
Publicado:	MDPI AG 2023-02-01
Series:	Biomolecules
Subjects:	enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism
Acceso en liña:	https://www.mdpi.com/2218-273X/13/2/329

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