Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4

High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established clearance pathway for lipid alkenals includes conjugation to gl...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Michele Scian, Lorela Paço, Taylor A. Murphree, Laura M. Shireman, William M. Atkins
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	MDPI AG 2023-02-01
Цуврал:	Biomolecules
Нөхцлүүд:	enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism
Онлайн хандалт:	https://www.mdpi.com/2218-273X/13/2/329

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