Conformational cycle of human polyamine transporter ATP13A2

Conformational cycle of human polyamine transporter ATP13A2

ATP13A2 is a lysosomal polyamine transporter, mutated in several diseases including juvenile-onset Parkinson’s disease. Here, the authors report structures of human ATP13A2 in six distinct intermediate states, illustrating most of its conformational cycle.

Bibliographic Details
Main Authors: Jianqiang Mu, Chenyang Xue, Lei Fu, Zongjun Yu, Minhan Nie, Mengqi Wu, Xinmeng Chen, Kun Liu, Ruiqian Bu, Ying Huang, Baisheng Yang, Jianming Han, Qianru Jiang, Kevin C. Chan, Ruhong Zhou, Huilin Li, Ancheng Huang, Yong Wang, Zhongmin Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37741-0

Internet

https://doi.org/10.1038/s41467-023-37741-0

Similar Items