Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin.

Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin.

A wide variety of drugs bind to human serum albumin (HSA) at its two principal sites, namely site I and site II. A number of reports indicate that drug binding to these two binding sites are not completely independent, and that interactions between ligands of these two discrete sites can play a role...

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Bibliographic Details
Main Authors: Keishi Yamasaki, Saya Hyodo, Kazuaki Taguchi, Koji Nishi, Noriyuki Yamaotsu, Shuichi Hirono, Victor Tuan Giam Chuang, Hakaru Seo, Toru Maruyama, Masaki Otagiri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5491222?pdf=render

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http://europepmc.org/articles/PMC5491222?pdf=render

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