Pathway mapping reveals antiretroviral treatments' targeted cell cycle regulation in lung cancer

Pathway mapping reveals antiretroviral treatments' targeted cell cycle regulation in lung cancer

The human cell cycle is a tightly regulated process with checkpoints in place to ensure genomic integrity. Cyclin/cyclin dependent kinases (CDKs) complexes drive the progression of the cell cycle while CDK-inhibitors (CDKIs) halt the cell cycle. Deregulation of the cell cycle is a hallmark of lung c...

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Bibliographic Details
Main Authors: Rahaba Marima, Rodney Hull, Jeyalakshmi Kandhavelu, Zodwa Dlamini, Clement Penny
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Cell cycle
Bioinformatics
p53
FOXO
Cyclin dependent kinases (CDKs)
Antiretroviral (ARV)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914820305761

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http://www.sciencedirect.com/science/article/pii/S2352914820305761

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