Toxin Instability and Its Role in Toxin Translocation from the Endoplasmic Reticulum to the Cytosol

Toxin Instability and Its Role in Toxin Translocation from the Endoplasmic Reticulum to the Cytosol

AB toxins enter a host cell by receptor-mediated endocytosis. The catalytic A chain then crosses the endosome or endoplasmic reticulum (ER) membrane to reach its cytosolic target. Dissociation of the A chain from the cell-binding B chain occurs before or during translocation to the cytosol, and only...

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Bibliographic Details
Main Author: Ken Teter
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Biomolecules
Subjects:
AB toxin
cholera toxin
cytolethal distending toxin
endoplasmic reticulum-associated degradation
exotoxin A
pertussis toxin
ricin toxin
Shiga toxin
toxin structure
ubiquitin-independent degradation
Online Access:http://www.mdpi.com/2218-273X/3/4/997

Internet

http://www.mdpi.com/2218-273X/3/4/997

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