Increased expression of TIGIT and KLRG1 correlates with impaired CD56bright NK cell immunity in HPV16-related cervical intraepithelial neoplasia

Increased expression of TIGIT and KLRG1 correlates with impaired CD56bright NK cell immunity in HPV16-related cervical intraepithelial neoplasia

Abstract Background The onset and progression of cervical intraepithelial neoplasia (CIN) are closely associated with the persistent infection of high-risk HPV (especially type16), which is mainly caused by immune escape. Natural killer (NK) cells play an important role against virally infected cell...

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Bibliographic Details
Main Authors: You Nie, Dandan Liu, Wen Yang, Yazhuo Li, Lihua Zhang, Xia Cheng, Ruyu Chen, Bingbing Yuan, Guangzheng Zhang, Hongwei Wang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Virology Journal
Subjects:
Cervical intraepithelial neoplasia
Human papillomavirus 16
Natural killer cell
Cytokines
TIGIT-PVR
KLRG1-Cadherin
Online Access:https://doi.org/10.1186/s12985-022-01776-4

Internet

https://doi.org/10.1186/s12985-022-01776-4

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