Design of live-attenuated animal vaccines based on pseudorabies virus platform

Design of live-attenuated animal vaccines based on pseudorabies virus platform

Abstract Pseudorabies virus (PRV) is a double-stranded DNA virus with a genome approximating 150 kb in size. PRV contains many non-essential genes that can be replaced with genes encoding heterogenous antigens without affecting viral propagation. With the ability to induce cellular, humoral and muco...

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Bibliographic Details
Main Authors:	Zhen Liu, Zhengjie Kong, Meng Chen, Yingli Shang
Format:	Article
Language:	English
Published:	BMC 2022-05-01
Series:	Animal Diseases
Subjects:	Recombinant pseudorabies virus Live-attenuated vaccine Swine CRISPR/Cas9
Online Access:	https://doi.org/10.1186/s44149-022-00044-w

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