The Cold-Adapted, Temperature-Sensitive SARS-CoV-2 Strain TS11 Is Attenuated in Syrian Hamsters and a Candidate Attenuated Vaccine

The Cold-Adapted, Temperature-Sensitive SARS-CoV-2 Strain TS11 Is Attenuated in Syrian Hamsters and a Candidate Attenuated Vaccine

Live attenuated vaccines (LAVs) replicate in the respiratory/oral mucosa, mimic natural infection, and can induce mucosal and systemic immune responses to the full repertoire of SARS-CoV-2 structural/nonstructural proteins. Generally, LAVs produce broader and more durable protection than current COV...

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Bibliographic Details
Main Authors: Jiayu Xu, Mingde Liu, Xiaoyu Niu, Juliette Hanson, Kwonil Jung, Peng Ru, Huolin Tu, Daniel M. Jones, Anastasia N. Vlasova, Linda J. Saif, Qiuhong Wang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
coronavirus
vaccine
cold-adaptation
temperature-sensitive
Online Access:https://www.mdpi.com/1999-4915/15/1/95

Internet

https://www.mdpi.com/1999-4915/15/1/95

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