Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas

Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas

Interferon Regulatory Factor 6 (IRF6) and Grainyhead Like Transcription Factor 3 (GRHL3) are transcription factors that orchestrate gene regulatory networks required for the balance between keratinocyte differentiation and proliferation. Absence of either protein results in the lack of a normal stra...

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Bibliographic Details
Main Authors: Ludovica Parisi, Carolin Mockenhaupt, Silvia Rihs, Farah Mansour, Christos Katsaros, Martin Degen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
IRF6
GRHL3
cancer
differentiation
tumor suppressor
orofacial cleft
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1023072/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1023072/full

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