Hepatocyte-Derived Prostaglandin E2-Modulated Macrophage M1-Type Polarization via mTOR-NPC1 Axis-Regulated Cholesterol Transport from Lysosomes to the Endoplasmic Reticulum in Hepatitis B Virus x Protein-Related Nonalcoholic Steatohepatitis

Hepatocyte-Derived Prostaglandin E2-Modulated Macrophage M1-Type Polarization via mTOR-NPC1 Axis-Regulated Cholesterol Transport from Lysosomes to the Endoplasmic Reticulum in Hepatitis B Virus x Protein-Related Nonalcoholic Steatohepatitis

Lipid metabolic dysregulation and liver inflammation have been reported to be associated with nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain unclear. Hepatitis B virus x protein (HBx) is a risk factor for NASH. Based on metabolomic and transcriptomic screens and public dat...

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Bibliographic Details
Main Authors: You Lan, Bo Qian, Hai-Yan Huang, Pan Wang, Ting Li, Qi Yuan, Han-Yu Zhang, Yu-Chun Lin, Zhong-Ning Lin
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis B virus x protein
prostaglandin E2
lysosomal mTOR-NPC1 signal axis
cholesterol transport
endoplasmic reticulum stress
macrophage M1-type polarization
Online Access:https://www.mdpi.com/1422-0067/23/19/11660

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https://www.mdpi.com/1422-0067/23/19/11660

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