TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

Abstract Background Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-centre, early phase trial in rheumatoid arthritis i...

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Bibliographic Details
Main Authors: M. Cole, C. Yap, C. Buckley, W. F. Ng, I. McInnes, A. Filer, S. Siebert, A. Pratt, J. D. Isaacs, D. D. Stocken
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Trials
Subjects:
CRM
Dose-finding
Adaptive
Early-phase
Clinical trial
Online Access:https://doi.org/10.1186/s13063-021-05384-5

Internet

https://doi.org/10.1186/s13063-021-05384-5

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