LpxK Is Essential for Growth of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates

LpxK Is Essential for Growth of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates

ABSTRACT Acinetobacter baumannii ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in the lipid A biosynthetic pathway) prevented growth of this strain due to toxic accumulation of lipid A pathwa...

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Bibliographic Details
Main Authors: Jun-Rong Wei, Daryl L. Richie, Mina Mostafavi, Louis E. Metzger, Christopher M. Rath, William S. Sawyer, Kenneth T. Takeoka, Charles R. Dean
Format: Article
Language:English
Published: American Society for Microbiology 2017-08-01
Series:mSphere
Subjects:
Acinetobacter baumannii
LpxK
lipid A
outer membrane
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00199-17

Internet

https://journals.asm.org/doi/10.1128/mSphere.00199-17

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