Synthesis and Characterization of New Functionalized 1,2,3-Triazole-Based Acetaminophen Derivatives via Click Chemistry from Expired Commercial Acetaminophen Tablets

Synthesis and Characterization of New Functionalized 1,2,3-Triazole-Based Acetaminophen Derivatives via Click Chemistry from Expired Commercial Acetaminophen Tablets

We hereby describe an efficient method for the preparation of a series of new 1-substituted 1,2,3-triazole-based acetaminophen derivatives through a clean, good-yielding, simple, and expeditious procedure based on the <i>O</i>-propargylation reaction of the acetaminophen (APAP) obtained...

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Bibliographic Details
Main Authors: Vladimir V. Kouznetsov, Daniela Calderón Lamus, Carlos E. Puerto Galvis
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Reactions
Subjects:
acetaminophen
1,4-disubstituted 1,2,3-triazoles
molecular hybrids
azide-alkyne cycloaddition
Huisgen reaction
Cu(PPh<sub>3</sub>)<sub>3</sub>Br catalyst
Online Access:https://www.mdpi.com/2624-781X/4/3/20

Internet

https://www.mdpi.com/2624-781X/4/3/20

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