Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages

Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages

Abstract We have previously reported the transcriptomic and lipidomic profile of the first-generation, hygromycin-resistant (HygR) version of the BCGΔBCG1419c vaccine candidate, under biofilm conditions. We recently constructed and characterized the efficacy, safety, whole genome sequence, and prote...

Full description

Bibliographic Details
Main Authors: Mario Alberto Flores-Valdez, Eliza J. R. Peterson, Michel de Jesús Aceves-Sánchez, Nitin S. Baliga, Yasu S. Morita, Ian L. Sparks, Deepak Kumar Saini, Rahul Yadav, Roland Lang, Dulce Mata-Espinosa, Juan Carlos León-Contreras, Rogelio Hernández-Pando
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
BCG
Tuberculosis
RNASeq
Transcriptomic
c-di-GMP
Lipids
Online Access:https://doi.org/10.1038/s41598-024-61815-8

Internet

https://doi.org/10.1038/s41598-024-61815-8

Similar Items