The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated sodium channels (VGSC) are inhibited within the same...

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Bibliographic Details
Main Authors: Benjamin Hackl, Peter Lukacs, Janine Ebner, Krisztina Pesti, Nicholas Haechl, Mátyás C Földi, Elena Lilliu, Klaus Schicker, Helmut Kubista, Anna Stary-Weinzinger, Karlheinz Hilber, Arpad Mike, Hannes Todt, Xaver Koenig
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
ivabradine
S16257
voltage-gated sodium channel
conduction cell
ventricular cardiomyocyte
atypical inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.809802/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.809802/full

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