A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format.

A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format.

High throughput screenings of single chain Fv (scFv) antibody phage display libraries are currently done as soluble scFvs produced in E.coli. Due to endotoxin contaminations from bacterial cells these preparations cannot be reliably used in mammalian cell based assays. The monovalent nature and lack...

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Bibliographic Details
Main Authors: Xiaodong Xiao, Yan Chen, Sheila Mugabe, Changshou Gao, Christine Tkaczyk, Yariv Mazor, Peter Pavlik, Herren Wu, William Dall'Acqua, Partha Sarathi Chowdhury
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0140691

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https://doi.org/10.1371/journal.pone.0140691

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