Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals...

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Bibliographic Details
Main Authors: Pradeepa Pushparaj, Andrea Nicoletto, Xaquin Castro Dopico, Daniel J. Sheward, Sungyong Kim, Simon Ekström, Ben Murrell, Martin Corcoran, Gunilla B. Karlsson Hedestam
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Virology
Subjects:
SARS-CoV-2
immunoglobulin germline genes
allelic diversity
copy number variation
antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full

Internet

https://www.frontiersin.org/articles/10.3389/fviro.2023.1128253/full

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