Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

Abstract Background Liver cancer, mainly hepatocellular carcinoma, is one of the deadliest cancers worldwide and has a poor prognosis due to insufficient understanding of hepatocarcinogenesis. Previous studies have revealed that the mutations in PTEN and TP53 are the two most common genetic events i...

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Bibliographic Details
Main Authors: Juanjuan Luo, Chunjiao Lu, Meilan Feng, Lu Dai, Maya Wang, Yang Qiu, Huilu Zheng, Yao Liu, Li Li, Bo Tang, Chuan Xu, Yajun Wang, Xiaojun Yang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pten
Tp53
Akt
Hepatocellular carcinoma
Zebrafish
Online Access:https://doi.org/10.1186/s13046-021-02061-y

Internet

https://doi.org/10.1186/s13046-021-02061-y

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