Holographic Quantitative Structure-Activity Relationships of Tryptamine Derivatives at NMDA, 5HT1A and 5HT2A Receptors

Holographic Quantitative Structure-Activity Relationships of Tryptamine Derivatives at NMDA, 5HT1A and 5HT2A Receptors

Tryptamine derivatives (Ts) were found to inhibit the binding of [3H]MK-801, [3H]ketanserin and [3H]8-OH-DPAT to rat brain membranes. [3H]MK-801 labels the NMDA (N-methyl-D-aspartate) receptor, a ionotropic glutamate receptor which controls synaptic plasticity and memory function in the brain, where...

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Bibliographic Details
Main Authors: Peter Wolschann, Rungtiva Palangsuntikul, Heinz Berner, Michael L. Berger
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Molecules
Subjects:
HQSAR
NMDA receptor
spermine
tryptamine
5HT2A receptor
5HT1A receptor
Online Access:http://www.mdpi.com/1420-3049/18/8/8799

Internet

http://www.mdpi.com/1420-3049/18/8/8799

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