Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese women.

The central component of the complement system, C3, is associated with obesity, metabolic syndrome and cardiovascular disease however the underlying reasons are unknown. In the present study we evaluated gene expression of C3, the cleavage product C3a/C3adesArg and its cognate receptor C3aR in subcu...

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Bibliographic Details
Main Authors: Abhishek Gupta, Reza Rezvani, Marc Lapointe, Pegah Poursharifi, Picard Marceau, Sunita Tiwari, Andre Tchernof, Katherine Cianflone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990631?pdf=render