Triazole Derivatives Target 14α–Demethylase (LDM) Enzyme in <i>Candida albicans</i> Causing Ergosterol Biosynthesis Inhibition

Triazole Derivatives Target 14α–Demethylase (LDM) Enzyme in <i>Candida albicans</i> Causing Ergosterol Biosynthesis Inhibition

<i>Candida albicans</i> is the most dominant and prevalent cause of fungal infections in humans. Azoles are considered as first-line drugs for the treatment of these infections. However, their prolonged and insistent use has led to multidrug resistance and treatment failures. To overcome...

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Bibliographic Details
Main Authors: Irfan A. Rather, Jamal S. M. Sabir, Amer H. Asseri, Mohmmad Younus Wani, Aijaz Ahmad
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Journal of Fungi
Subjects:
triazole derivatives
<i>C. albicans</i>
ergosterol
molecular docking
simulation
Online Access:https://www.mdpi.com/2309-608X/8/7/688

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https://www.mdpi.com/2309-608X/8/7/688

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