Constitutively active androgen receptor variants upregulate expression of mesenchymal markers in prostate cancer cells.

Constitutively active androgen receptor variants upregulate expression of mesenchymal markers in prostate cancer cells.

Androgen receptor (AR) signaling pathway remains the foremost target of novel therapeutics for castration-resistant prostate cancer (CRPC). However, the expression of constitutively active AR variants lacking the carboxy-terminal region in CRPC may lead to therapy inefficacy. These AR variants are s...

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Bibliographic Details
Main Authors: Félicie Cottard, Irène Asmane, Eva Erdmann, Jean-Pierre Bergerat, Jean-Emmanuel Kurtz, Jocelyn Céraline
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3642121?pdf=render

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http://europepmc.org/articles/PMC3642121?pdf=render

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