EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway

EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway

Abstract Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circRNA, Circ_0001187, which is downregulated in AML patients, and its low level contri...

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Bibliographic Details
Main Authors: Xinyu Yang, Fengjiao Han, Xiang Hu, Guosheng Li, Hanyang Wu, Can Can, Yihong Wei, Jinting Liu, Ruiqing Wang, Wenbo Jia, Chunyan ji, Daoxin Ma
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Biomarker Research
Subjects:
Circ_0001187
METTL3
RNF113A
miR-499a-5p
Acute myeloid leukemia
Progression
Online Access:https://doi.org/10.1186/s40364-023-00495-4

Internet

https://doi.org/10.1186/s40364-023-00495-4

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