EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway
Abstract Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circRNA, Circ_0001187, which is downregulated in AML patients, and its low level contri...
Main Authors: | Xinyu Yang, Fengjiao Han, Xiang Hu, Guosheng Li, Hanyang Wu, Can Can, Yihong Wei, Jinting Liu, Ruiqing Wang, Wenbo Jia, Chunyan ji, Daoxin Ma |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-06-01
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Series: | Biomarker Research |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40364-023-00495-4 |
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