Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes.

Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes.

Cigarette smoke (CS) causes sustained lung inflammation, which is an important event in the pathogenesis of chronic obstructive pulmonary disease (COPD). We have previously reported that IKKα (I kappaB kinase alpha) plays a key role in CS-induced pro-inflammatory gene transcription by chromatin modi...

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Bibliographic Details
Main Authors: Isaac K Sundar, Sangwoon Chung, Jae-Woong Hwang, John D Lapek, Michael Bulger, Alan E Friedman, Hongwei Yao, James R Davie, Irfan Rahman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3270039?pdf=render

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http://europepmc.org/articles/PMC3270039?pdf=render

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