MEK Is a Potential Indirect Target in Subtypes of Head and Neck Cancers

MEK Is a Potential Indirect Target in Subtypes of Head and Neck Cancers

The poor prognosis of head-and-neck squamous cell carcinoma (HNSCC) is partly due to the lack of reliable prognostic and predictive markers. The Ras/Raf/MEK/ERK signaling pathway is often activated by overexpressed epidermal growth factor receptor (EGFR) and stimulates the progression of HNSCCs. Our...

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Bibliographic Details
Main Authors: Bianka Gurbi, Diána Brauswetter, Kinga Pénzes, Attila Varga, Tibor Krenács, Kornél Dános, Ede Birtalan, László Tamás, Miklós Csala
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
head-and-neck cancer
epidermal growth factor receptor
MEK
feedback loop
Online Access:https://www.mdpi.com/1422-0067/24/3/2782

Internet

https://www.mdpi.com/1422-0067/24/3/2782

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