RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling

RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling

Structural plasticity, the ability of dendritic spines to change their volume in response to synaptic stimulation, is an essential determinant of synaptic strength and long-term potentiation (LTP), the proposed cellular substrate for learning and memory. Branched actin polymerization is a major forc...

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Bibliographic Details
Main Authors: Kai Sempert, Belal Shohayeb, Vanessa Lanoue, Elizabeth A. O’Brien, Cecilia Flores, Helen M. Cooper
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spine enlargement
actin cytoskeleton
synapse formation
Neogenin
RGMa
netrin receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1253801/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1253801/full

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