Comparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamer.
Noncanonically structured DNA aptamers to thrombin were examined. Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer. These approaches are chemical modification and the addition of a duplex module to the aptamer core...
| Main Authors: | , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Public Library of Science (PLoS)
2014-01-01
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| 丛编: | PLoS ONE |
| 在线阅读: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089383&type=printable |