NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. NADPH is a central co-factor for both lipid and redox...

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Bibliographic Details
Main Authors: Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Redox Biology
Subjects:
Metastasis
Breast cancer
Redox
NADPH
NADK
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000289

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http://www.sciencedirect.com/science/article/pii/S2213231723000289

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