Septic arthritis in an in vivo murine model induced by Staphylococcus aureus <subtitle>a comparison between actions of the haemolysin toxin and the effects of the host immune response</subtitle>

Septic arthritis in an in vivo murine model induced by Staphylococcus aureus <subtitle>a comparison between actions of the haemolysin toxin and the effects of the host immune response</subtitle>

AimsStaphylococcus aureus is a major cause of septic arthritis, and in vitro studies suggest α haemolysin (Hla) is responsible for chondrocyte death. We used an in vivo murine joint model to compare inoculation with wild type S. aureus 8325-4 with a Hla-deficient strain DU1090 on chondrocyte viabili...

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Bibliographic Details
Main Authors: Rhys G. E. Clement, Andrew C. Hall, Seng J. Wong, Sarah E. M. Howie, A. Hamish R. W. Simpson
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2022-09-01
Series:Bone & Joint Research
Subjects:
Septic arthritis
Hla toxin
Cartilage
Chondrocyte
Staphylococcus aureus
septic arthritis
Online Access:https://online.boneandjoint.org.uk/doi/10.1302/2046-3758.119.BJR-2022-0016.R1

Internet

https://online.boneandjoint.org.uk/doi/10.1302/2046-3758.119.BJR-2022-0016.R1

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