Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries

Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries

Antisense oligonucleotides are short, single-stranded nucleic acid analogues that can interfere with pre-messenger RNA (pre-mRNA) processing and induce excision of a targeted exon from the mature transcript. When developing a panel of antisense oligonucleotides to skip every dystrophin exon, we foun...

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Bibliographic Details
Main Authors: Khine Zaw, Kane Greer, May Thandar Aung-Htut, Chalermchai Mitrpant, Rakesh N. Veedu, Sue Fletcher, Steve D. Wilton
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Genetics
Subjects:
DMD
antisense oligonucleotide
locked nucleic acid
locked nucleic acid/2′-O-methyl mixmer
cryptic splice site
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01249/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01249/full

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