Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer’s disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of most...

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Bibliographic Details
Main Authors: Loes Koelewijn, Thomas M Lancaster, David Linden, Diana C Dima, Bethany C Routley, Lorenzo Magazzini, Kali Barawi, Lisa Brindley, Rachael Adams, Katherine E Tansey, Aline Bompas, Andrea Tales, Antony Bayer, Krish Singh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
neural oscillations
functional connectivity
APOE-ɛ4
Alzheimer's disease
parietal cortex
Online Access:https://elifesciences.org/articles/36011

Internet

https://elifesciences.org/articles/36011

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