Ribosome•RelA structures reveal the mechanism of stringent response activation

Ribosome•RelA structures reveal the mechanism of stringent response activation

Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amino-acid starvation, when cognate deacyl-tRNA binds...

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Bibliographic Details
Main Authors: Anna B Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F Brilot, Nikolaus Grigorieff, Andrei A Korostelev
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
RelA
ribosome
stringent response
cryo-EM
cognate tRNA
decoding
Online Access:https://elifesciences.org/articles/17029

Internet

https://elifesciences.org/articles/17029

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