Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with neuron–glia dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR-21 in AD neurons and their exosomes. However, their glial distribution, phenotypic alterations and exosomal spread are scarcely doc...

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Bibliographic Details
Main Authors: Gonçalo Garcia, Sara Pinto, Sofia Ferreira, Daniela Lopes, Maria João Serrador, Adelaide Fernandes, Ana Rita Vaz, Alexandre de Mendonça, Frank Edenhofer, Tarja Malm, Jari Koistinaho, Dora Brites
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
CSF miRNAs
exosomal miRNAs
glial activation
hippocampal neuroblastoma transplantation
immunostimulated astrocytes
inflammation-associated miRNAs
Online Access:https://www.mdpi.com/2073-4409/11/21/3377

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https://www.mdpi.com/2073-4409/11/21/3377

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