ATP/ADP biosensor organoids for drug nephrotoxicity assessment

ATP/ADP biosensor organoids for drug nephrotoxicity assessment

Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal experiments for nephrotoxicity assessment. Here we...

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Bibliographic Details
Main Authors: Koichiro Susa, Kenichi Kobayashi, Pierre Galichon, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Navin R. Gupta, Iman K. Yazdi, Joseph V. Bonventre, Ryuji Morizane
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nephron
organoid
ATP
drug development
transporter
kidney
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1138504/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1138504/full

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